11/14/2023 0 Comments Rita chopra nomura![]() Furthermore, in the 123 TNBC cases, the prognosis of patients with an E-cadherin-negative expression was significantly worse than that of E-cadherin-positive patients ( P=0.0265), especially for those in clinical stage II ( P=0.002). E-cadherin reduction was significantly frequent in cases of TNBC ( P<0.001) and lymph node metastasis ( P=0.032). Reduced levels of E-cadherin were observed in 238 (41.5%) of the 574 breast cancer cases. Triple-negative breast cancer was an independent prognostic factor. Patients with TNBC experienced more frequent lymph node metastasis ( P=0.024) and a poorer prognosis ( P<0.001) in comparison with non-TNBC patients. Results:Īmong the 574 breast cancer cases, 123 (21.4%) revealed a triple-negative phenotype. We examined the association between TNBC and other clinicopathological variables and evaluated the significance of the E-cadherin expression. Expressions of ER, PR, HER2, and E-cadherin were assessed by immunohistochemistry. Methods:Ī total of 574 patients who had undergone a resection of a primary breast cancer except for invasive lobular carcinomas were enrolled in this study. Although a correlation between E-cadherin expression level and outcome has been demonstrated among all types of breast cancer, little is known about the significance of E-cadherin expression levels in TNBC. Triple-negative breast cancer (TNBC), a subtype of breast cancer that is oestrogen receptor (ER) negative, progesterone receptor (PR) negative, and human epidermal growth factor receptor 2 (HER2) negative, has a poor prognosis.
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